Blar i forfatter "van der Wal, Yorick Andreas"

Viser treff 1-5 av 5

    • Atlantic salmon immune responses after infection with intracellular pathogens 

      van der Wal, Yorick Andreas (Doctoral thesis; Doktorgradsavhandling, 2023-02-21)
      We focused on the responses of two arms of the Atlantic salmon immune system against intracellular pathogens: the antibody (Ab) production by B cells after challenge with the facultative intracellular bacterium <i>Pisciricketsia salmonis</i> and the interferon (IFN) responses in a salmonid cell line against salmon alphavirus (SAV), infectious necrotic pancreas virus (IPNV), and <i>P. salmonis</i>. ...

    • CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication 

      van der Wal, Yorick Andreas; Nordli, Henriette R.; Akandwanaho, Allan; Greiner-Tollersrud, Linn; Kool, Jaap; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Background: Interferon (IFN) responses are critical in the resolution of viral infections and are actively targeted by many viruses. They also play a role in inducing protective responses after vaccination and have been successfully tested as vaccine adjuvants. IFN responses are well conserved and function very similar in teleosts and mammals. Like in mammals, IFN responses in piscine cells are ...

    • The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection 

      van der Wal, Yorick Andreas; Jenberie, Shiferaw; Nordli, Henriette; Greiner-Tollersrud, Linn; Kool, Jaap; Jensen, Ingvill; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)
      The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response ...

    • Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish 

      Bela-Ong, Dennis; Greiner-Tollersrud, Linn; van der Wal, Yorick Andreas; Jensen, Ingvill; Seternes, Ole Morten; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
      Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by ...

    • Microbial danger signals control transcriptional induction of distinct MHC class I L lineage genes in Atlantic salmon 

      Svenning, Steingrim; Gondek-Wyrozemska, Agata T; van der Wal, Yorick Andreas; Robertsen, Børre; Jensen, Ingvill; Jørgensen, Jorunn B; Edholm, Eva-Stina Isabella (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-11)
      Antigen processing and presentation by major histocompatibility complex (MHC) molecules is a cornerstone in vertebrate immunity. Like mammals, teleosts possess both classical MHC class I and multiple families of divergent MHC class I genes. However, while certain mammalian MHC class I-like molecules have proven to be integral in immune regulation against a broad array of pathogens, the biological ...